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. 2012 Sep 26;32(39):13529–13536. doi: 10.1523/JNEUROSCI.3077-12.2012

Figure 5.

Figure 5.

MeCP2 knock-out blocks homeostatic synaptic scaling in vivo. A, Average waveform for mEPSCs recorded from WT (left) and KO (right) neurons from DE and normal 12 h light/dark cycle Ctl mice: WT_Ctl (n = 5 animals), WT_DE (n = 4 animals), KO_Ctl (n = 2 animals), and KO_DE (n = 2 animals). B, Cumulative histogram of mEPSC amplitudes recorded from Ctl (n = 23) and DE (n = 32) WT mice. Inset, Average mEPSC amplitudes for the same conditions. C, Cumulative histogram of mEPSC amplitudes recorded from Ctl (n = 24) and DE (n = 35) KO mice. Inset, Average mEPSC amplitudes for the same conditions. D, Cumulative histogram of mEPSC amplitudes for WT and KO neurons from Ctl mice. Inset, Average mEPSC amplitude for the same conditions. E, Average frequency (left) and input resistance (right) for WT and KO neurons from ctl mice. *p < 0.05, different from WT_Ctl. Cumul. Prob., Cumulative probability.