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. Author manuscript; available in PMC: 2013 Sep 18.
Published in final edited form as: Anal Chem. 2012 Aug 31;84(18):8067–8074. doi: 10.1021/ac3019813

Figure 1.

Figure 1

(a) Real-time shifts in microring resonances accompanying target hybridization highlight that despite over an 80-fold increase in size, full length mRNA elicits a much lower sensor response than smaller miRNA molecules based on steric inhibition and diffusion limitations. (b) Small DNA chaperones were pre-hybridized to a 2.56 nM concentration of myc mRNA before being flowed across an array of ssDNA-presenting microring resonators. The chaperone/mRNA mixture was introduced to the sensor array at t=0 minutes, and the resultant responses demonstrate the enhanced rate of target binding in the presence of chaperones.