Table 2.

Estimated Prevalence and Number of Alpha-1-Antitrypsin Deficiency in Patients with Chronic Obstructive Pulmonary Disease and in Serbian Population Without Chronic Obstructive Pulmonary Disease

	Observed number	Observed frequency	Expected number	Expected frequency	Estimated prevalencea	Estimated numberb
COPD (n=348)
Phenotypes
MM	305	0.8764	297.05	0.8535	/	/
MZ	29	0.0833	45.27	0.1300	1:8	55,578
ZZ	10	0.0287	1.72	0.0049	1:202	2112
MS	4	0.0115	3.66	0.0105	1:95	4493
SZ	0	0	0.28	0.0008	1:1243	344
SS	0	0	0.01	0.0001	1:34,800	12
Alleles
M	643	0.9239
Z	49	0.0704
S	4	0.0057
Control (n=1435)
Phenotypes
MM	1378	0.9603	1377.6	0.9600	/	/
MZ	37	0.0258	37.97	0.0264	1:38	177,108
ZZ	1	0.0007	0.26	0.0002	1:5519	1212
MS	19	0.0132	18.37	0.0128	1:78	85,685
SZ	0	0	0.26	0.0002	1:5519	1212
SS	0	0	0.06	0.0000	1:23,917	280
Alleles
M	2812	0.9798
Z	39	0.0136
S	19	0.0066

^aPrevalence of COPD in Serbia is 6%; for the calculation, the estimated number of 427,240 patients with COPD was used.

^bPopulation of Serbia consists of 7,120,666 inhabitants; for the calculation, the estimated number of 6,693,426 individuals without COPD was used.