TABLE 1.
Description of candidate SNPs for proposed dietary associations
| Symbol | Location | SNP | SNP Base | MAF | Major/Minor Allele | FDR HWE | Colon
|
Rectal
|
||
|---|---|---|---|---|---|---|---|---|---|---|
| Heterozygote OR | Homozygote Rare OR | Heterozygote OR | Homozygote Rare OR | |||||||
| AKT1 | 14q32.32 | rs2494738 | 104317731 | 0.07 | G/A | 0.62 | 1.05 (0.87, 1.27)* | 1.02 (0.78, 1.33)* | ||
| PDK1 | 2q31.1 | rs11904366 | 173170476 | 0.15 | G/T | 1.00 | 1.04 (0.89, 1.21) | 1.10 (0.73, 1.67) | 0.87 (0.70, 1.09) | 0.69 (0.35, 1.35) |
| rs4972842 | 173137279 | 0.19 | T/A | 1.00 | 0.88 (0.76, 1.03) | 0.95 (0.66, 1.37) | 0.85 (0.69, 1.06) | 1.43 (0.88, 2.33) | ||
| PRKAG2 | 7q36.1 | rs6464156 | 150950488 | 0.5 | A/G | 0.85 | 0.84 (0.71, 0.98) | 0.82 (0.67, 0.99) | 1.14 (0.91, 1.43) | 0.97 (0.73, 1.27) |
| rs1881632 | 151147274 | 0.2 | C/T | 1.00 | 1.11 (0.96, 1.29) | 1.02 (0.71, 1.45) | 0.95 (0.77, 1.17) | 0.80 (0.48, 1.32) | ||
| rs9632641 | 151106857 | 0.2 | A/C | 0.79 | 1.15 (1.00, 1.33) | 1.28 (0.92, 1.78) | 0.92 (0.74, 1.14) | 0.72 (0.44, 1.17) | ||
| rs9648723 | 151026570 | 0.18 | A/C | 0.98 | 0.96 (0.82, 1.11) | 1.48 (1.07, 2.06) | 1.06 (0.86, 1.31) | 0.63 (0.40, 1.00) | ||
| rs1104897 | 151063507 | 0.14 | G/A | 1.00 | 1.19 (1.02, 1.39) | 1.46 (0.94, 2.26) | 1.22 (0.99, 1.52) | 1.88 (1.08, 3.27) | ||
| rs4725431 | 151104112 | 0.16 | T/C | 1.00 | 1.06 (0.91, 1.23) | 0.97 (0.63, 1.48) | 0.80 (0.64, 1.01) | 0.70 (0.38, 1.28) | ||
| rs6464170 | 151107793 | 0.22 | C/G | 0.96 | 1.06 (0.92, 1.22) | 0.75 (0.55, 1.01) | 1.09 (0.89, 1.34) | 1.03 (0.69, 1.53) | ||
| rs9648724 | 151133235 | 0.25 | G/A | 0.95 | 0.89 (0.77, 1.03) | 0.74 (0.55, 1.00) | 0.80 (0.65, 0.98) | 0.67 (0.43, 1.04) | ||
| PTEN | 10q23.3 | rs532678 | 89713322 | 0.34 | C/T | 1.00 | 0.92 (0.80, 1.06) | 0.92 (0.74, 1.15) | 1.25 (1.01, 1.53) | 1.25 (0.92, 1.69) |
| RPS6KA1 | 1p | rs12025634 | 26738092 | 0.15 | C/T | 0.57 | 1.00 (0.85, 1.16) | 1.74 (1.08, 2.79) | 0.86 (0.69, 1.08) | 0.91 (0.44, 1.88) |
| RPS6KA2 | 6q27 | rs16898963 | 166802654 | 0.12 | A/C | 0.39 | 1.01 (0.86, 1.19) | 2.28 (1.27, 4.09) | 0.95 (0.76, 1.20) | 0.94 (0.41, 2.17) |
| rs2072638 | 167108340 | 0.3 | T/C | 0.25 | 1.23 (1.06, 1.42) | 1.17 (0.94, 1.46) | 1.02 (0.83, 1.26) | 1.77 (1.28, 2.45) | ||
| TSC1 | 9q34 | rs11243940 | 134811193 | 0.23 | A/G | 1.00 | 1.05 (0.91, 1.21) | 1.26 (0.93, 1.70) | 0.99 (0.81, 1.21) | 0.91 (0.59, 1.40) |
| TSC2 | 16p13.3 | rs3087631 | 2079128 | 0.18 | A/T | 0.38 | 1.07 (0.92, 1.24) | 0.68 (0.48, 0.95) | 1.10 (0.89, 1.36) | 0.79 (0.50, 1.27) |
OR, odds ratio; FDR HWE = False Discovery Rate Hardy Weinberg Equilibrium.
*
Indicates dominant model used due to MAF < 0.1.