TABLE 3.
Associations between low- and high-risk diet and genetic variation and risk of colon cancer
| Low Diet Risk*
|
Intermediate diet risk
|
High Diet Risk**
|
P interaction | ||||
|---|---|---|---|---|---|---|---|
| OR | (95% CI) | OR | (95% CI) | OR | (95% CI) | ||
| PDK1 rs11904366 (G > T) & PTEN rs532678 (C > T) | |||||||
| G-C | 1.00 | 1.04 | (0.88, 1.22) | 1.18 | (1.00, 1.39) | 0.0008 | |
| G-T | 0.82 | (0.66, 1.02) | 1.00 | (0.83, 1.22) | 1.20 | (0.99, 1.45) | |
| T-C | 0.73 | (0.53, 1.01) | 1.23 | (0.94, 1.61) | 1.41 | (1.07, 1.85) | |
| T-T | 0.64 | (0.41, 1.00) | 1.07 | (0.74, 1.55) | 1.42 | (1.02, 1.99) | |
| PRKAG2 rs1881632 (C > T) & PTEN rs532678 (C > T) | |||||||
| C-C | 1.00 | 1.13 | (0.96, 1.34) | 1.23 | (1.04, 1.45) | 0.0296 | |
| C-T | 0.85 | (0.68, 1.06) | 1.06 | (0.87, 1.29) | 1.28 | (1.06, 1.55) | |
| T-C | 1.03 | (0.77, 1.37) | 1.11 | (0.86, 1.44) | 1.51 | (1.18, 1.93) | |
| T-T | 0.78 | (0.51, 1.17) | 1.13 | (0.80, 1.58) | 1.42 | (1.02, 1.96) | |
| AKT1 rs2494738 (G > A) & PDK1 rs11904366 (G > T) | |||||||
| G-G | 1.00 | 1.09 | (0.95, 1.25) | 1.25 | (1.09, 1.43) | 0.0005 | |
| G-T | 0.76 | (0.58, 1.00) | 1.23 | (0.98, 1.55) | 1.53 | (1.22, 1.92) | |
| A-G | 0.85 | (0.57, 1.26) | 1.18 | (0.84, 1.65) | 1.52 | (1.09, 2.11) | |
| A-T | 0.51 | (0.20, 1.29) | 1.67 | (0.82, 3.40) | 1.55 | (0.75, 3.21) | |
| PDK1 rs11904366 (G > T) & TSC1 rs11243940 (A > G) | |||||||
| G-A | 1.00 | 1.08 | (0.92, 1.25) | 1.31 | (1.12, 1.52) | 0.0003 | |
| G-G | 1.13 | (0.89, 1.43) | 1.33 | (1.07, 1.65) | 1.30 | (1.05, 1.61) | |
| T-A | 0.80 | (0.59, 1.08) | 1.21 | (0.94, 1.56) | 1.63 | (1.27, 2.09) | |
| T-G | 0.69 | (0.41, 1.14) | 1.60 | (1.06, 2.44) | 1.32 | (0.86, 2.01) | |
| PRKAG2 rs4725431 (T > C) & PTEN rs532678 (C > T) | |||||||
| T-C | 1.00 | 1.15 | (0.98, 1.36) | 1.30 | (1.10, 1.53) | 0.0501 | |
| T-T | 0.82 | (0.66, 1.02) | 1.08 | (0.89, 1.31) | 1.27 | (1.05, 1.53) | |
| C-C | 1.10 | (0.80, 1.52) | 1.07 | (0.82, 1.40) | 1.24 | (0.95, 1.62) | |
| C-T | 0.95 | (0.63, 1.45) | 1.09 | (0.76, 1.56) | 1.56 | (1.12, 2.17) | |
Adjusted for age, center, race, and sex. OR indicates odds ratios.
*
Includes individuals in tertile 1 of dietary fat and tertile 3 of carbohydrates.
**
Includes individuals in tertile 3 of Fat and tertile 1 of Carbohydrates, tertile 3 of Fat and tertile 2 of Carbohydrates, tertile 2 of Fat and tertile 1 of Carbohydrate; intermediate risk includes all others.