TABLE 4.
Associations between low- and high-risk diet and genetic variation and risk of rectal cancer
| Low Diet Risk*
|
Intermediate Diet Risk
|
High Diet risk**
|
P interaction | ||||
|---|---|---|---|---|---|---|---|
| OR | (95% CI) | OR | (95% CI) | OR | (95% CI) | ||
| PRKAG2 rs4725431 (T > C) & TSC2 rs3087631 (A > T) | |||||||
| T-A | 1.00 | 1.61 | (1.13, 2.28) | 2.10 | (1.42, 3.10) | 0.01 | |
| T-T | 1.39 | (0.62, 3.12) | 1.51 | (1.02, 2.23) | 2.49 | (1.50, 4.16) | |
| C-A | 0.60 | (0.23, 1.53) | 1.45 | (0.96, 2.17) | 1.30 | (0.73, 2.33) | |
| C-T | 0.85 | (0.12, 6.09) | 1.01 | (0.57, 1.80) | 2.82 | (1.09, 7.27) | |
| PDK1 rs11904366 (G > T) & PTEN rs532678 (C > T) | |||||||
| G-C | 1.00 | 1.83 | (1.21, 2.76) | 2.26 | (1.44, 3.57) | 0.0004 | |
| G-T | 1.66 | (0.88, 3.13) | 2.03 | (1.33, 3.10) | 2.54 | (1.55, 4.15) | |
| T-C | 1.62 | (0.64, 4.07) | 1.36 | (0.84, 2.18) | 2.94 | (1.48, 5.83) | |
| T-T | 0.11 | (0.01, 1.88) | 1.86 | (1.11, 3.14) | 3.39 | (1.45, 7.91) | |
| PRKAG2 rs1881632 (C > T) & PTEN rs532678 (C > T) | |||||||
| C-C | 1.00 | 1.92 | (1.24, 2.96) | 2.51 | (1.56, 4.05) | 0.0219 | |
| C-T | 1.24 | (0.62, 2.49) | 2.26 | (1.45, 3.53) | 2.79 | (1.67, 4.66) | |
| T-C | 1.94 | (0.84, 4.44) | 1.74 | (1.08, 2.81) | 2.53 | (1.37, 4.66) | |
| T-T | 2.05 | (0.76, 5.53) | 1.75 | (1.05, 2.92) | 3.01 | (1.45, 6.26) | |
OR indicates odds ratio. Adjusted for age, center, race, and sex.
*
Includes individuals in tertile 1 of dietary fat and tertile 3 of both carbohydrates and fiber.
**
Includes individuals in tertile 3 of Fat and tertile 1 of both carbohydrates and fiber, tertile 3 of fat and tertile 2 of both carbohydrates and fiber, tertile 2 of fat and tertile 1 of both carbohydrates and fiber. Intermediate risk includes all others.