Table 3.
Primary | Stage | Best Response (RECIST) | Duration of Resp. (Months) | History of brain metastases | Site of progression | ELIspot* | |
---|---|---|---|---|---|---|---|
Day 50 | Day 90 | ||||||
1. Unknown | M1a | PD | 0 | yes | brain, LN | n | NE |
2. Cutaneous | M1b | SD | 4 | 0 | LN, lung | n | n |
3. Cutaneous | M1c | PD | 0 | yes | subQ, LN | NE | NE |
4. Cutaneous | M1a | SD | 7 | 0 | LN | p | p |
5. Cutaneous | M1c | PR | 2 | 0 | liver | n | p |
6. Cutaneous | M1b | PD | 0 | 0 | lung | p | NE |
7. Cutaneous | M1b | SD | 2 | 0 | lung | n | n |
8. Cutaneous | M1b | PD | 0 | 0 | lung | p | NE |
9. Cutaneous | NE | NE | NE | yes | NE | NE | NE |
10. Unknown | M1c | PD | 0 | 0 | LN, subQ | n | NE |
11. Cutaneous | M1c | SD | 4 | yes | brain | p | n |
12. Unknown | M1c | SD | 2 | yes | brain, lung | n | n |
13. Unknown | M1c | SD | 6 | yes | brain | p | p |
14. Cutaneous | M1a | PD | 0 | 0 | subQ | n | NE |
15. Cutaneous | M1c | PD | 0 | yes | brain, bone, liver, lung | n | NE |
16. Cutaneous | M1c | PD | 0 | yes | brain | p | NE |
17. Cutaneous | M1c | PD | 0 | 0 | liver, lung, muscle, subQ | n | NE |
18. Cutaneous | M1a | PD | 0 | 0 | liver, LN, subQ | n | NE |
19. Cutaneous | M1a | PD | 0 | 0 | LN, subQ | n | NE |
20. Cutaneous | M1c | SD | 2 | 0 | LN | p | p |
21. Mucosal | M1b | SD | 2 | 0 | Lung | p | p |
22. Cutaneous | M1b | PR | 2+ | 0 | NA | n | n |
NE: non-evaluable; LN: lymph node; subQ: subcutaneous; NA: non-applicable; p=positive; n=negative
Twenty patients had day 50 samples for ELIspot testing and only 10 had day 90 samples