Table 4.

Ado and Ino transport in rabbit and guinea pig hearts

Expt. No.	Solute	Cleft	Endothelial Cell		Myocyte
		PS_g (AraH), ml · g⁻¹ · min⁻¹	PS_ecl, ml · g⁻¹ · min⁻¹	G_ec, ml · g⁻¹ · min⁻¹	PS_pc, ml · g⁻¹ · min⁻¹	G_pc, ml · g⁻¹ · min⁻¹	CV, %
		PS_g (AraH), ml · g⁻¹ · min⁻¹	PS_ecl, ml · g⁻¹ · min⁻¹	G_ec, ml · g⁻¹ · min⁻¹	PS_pc, ml · g⁻¹ · min⁻¹	G_pc, ml · g⁻¹ · min⁻¹	AraH	Permeant
Rabbit
0103881	Ino	2.98	0.1 ± 0.0	2 ± 4	36 ± 7	1.4 ± 0.3	1.1	2.2
2502884	Ino	3.94	0.4 ± 0.1	3 ± 2	36 ± 2	2.5 ± 0.7	2.8	7.2
2010871	Ino	5.18	0.0 ± 0.0	0 ± 0	27 ± 7	3.5 ± 0.6	2.7	8.2
2010872	Ino	4.96	0.0 ± 0.0	0 ± 0	26 ± 5	3.8 ± 0.5	3.1	6.3
Mean ± SD		4.3 ± 1.0	0.1 ± 0.2	1 ± 2	31 ± 6	2.8 ± 1.1
0103882	Ado	2.57	0.3 ± 0.2	6 ± 5	19 ± 5	20 ± 5	3.2	5.0
2502885	Ado	3.95	0.2 ± 0.1	10 ± 25	29 ± 15	23 ± 10	3.3	3.2
2010873	Ado	4.06	0.1 ± 0.1	1 ± 43	20 ± 7	62 ± 43	4.3	4.7
2010874	Ado	3.75	0.1 ± 0.1	4 ± 23	29 ± 12	15 ± 5	2.7	4.1
Mean ± SD		3.6 ± 0.7	0.2 ± 0.1	5 ± 4	24 ± 6	30 ± 21
All rabbits		3.92 ± 0.88
Guinea pig
0103884	Ino	3.23	1.9 ± 0.3	27 ± 22	76 ± 24	19 ± 6	4.4	6.2
2502881	Ino	2.30	1.5 ± 0.2	22 ± 5	36 ± 13	22 ± 13	6.9	5.1
2409871	Ino	2.31	2.0 ± 0.4	13 ± 9	99 ± 9	23 ± 9	5.4	16.5
2409872	Ino	2.12	1.3 ± 0.2	2 ± 11	49 ± 11	49 ± 11	6.1	5
Mean±SD		2.5 ± 0.5	1.7 ± 0.4	16 ± 11	65 ± 28	28 ± 14
0103885	Ado	3.77	2.7 ± 0.2	50 ± 29	77 ± 26	109 ± 29	2.3	8.4
2502882	Ado	2.39	2.0 ± 0.2	14 ± 3	15 ± 3	17 ± 3	6.5	10.3
2409873	Ado	2.36	1.8 ± 1.4	14 ± 178	40 ± 128	56 ± 181	9.5	10.9
2409874	Ado	2.17	1.4 ± 0.2	83 ± 311	224 ± 310	245 ± 309	4.4	8.4
Mean±SD		2.7 ± 0.7	2.0 ± 0.5	40 ± 33	89 ± 93	107 ± 100
All guinea pigs		2.58 ± 0.59

Values taken for PS_g for Ino and Ado are those found for AraH. Each parameter is estimated from the model fit to the data set and reported as mean ± SD of estimate computed from covariance matrix calculated from local sensitivity functions for all free parameters. G_ec and G_pc, first-order clearance by consumption or gulosity in endothelial cells and parenchymal cells (myocytes), respectively; CV, coefficient of variation.