Table 1.

Effect of the fish oil diets on endocannabinoid/NAE levels in plasma, liver, ileum and adipose tissue (diet effect)

			Plasma	Liver	Ileum	Adi. tiss.
Ctrl vs 1 % FO	n-3 derived	EPEA	2.51	*	24.159	43.096
		DHEA	1.915	2.908	2.123	3.241
	Other	AEA	*	0.312	0.374	0.350
		2-AG	0.403	0.216	0.304	0.465
		DGLEA	0.282	–	0.650	0.562
		OEA	0.710	0.777	–	*
Ctrl vs 3 % FO	n-3 derived	EPEA	3.688	*	67.069	116.975
		DHEA	2.166	4.691	2.774	5.484
	Other	AEA	*	–	0.811	0.423
		2-AG	0.301	0.156	0.272	0.607
		DGLEA	0.250	–	↓	0.578
		OEA	0.522	0.663	–	*
		SEA	0.692	–	–	1.574
1 % FO vs 3 % FO	n-3 derived	EPEA	–	*	2.776	2.714
		DHEA	–	1.613	1.306	1.692
	Other	2-AG	–	0.724	–	1.304
		OEA	0.735	–	–	*
		SEA	0.700	–	–	1.284

Only statistically significant effects are listed, presented as fold-control values, calculated by comparing mean metabolite concentration from one diet to another. Means were calculated from saline and LPS treated animals together per diet group. ↑ or ↓ were used when the fold-control value would disagree with the outcome outcome of the ANOVA in cases of variables which were rank-transformed

ND the compound was not detected in the particular matrix, and – indicates that no statistical significant differences were observed

* Interaction effect (see supplemental data for details)