Table 4.
Effect of LPS on oxylipin levels in plasma, liver, ileum and adipose tissue (LPS effect)
| Plasma | Liver | Ileum | Adi. tiss. | |||
|---|---|---|---|---|---|---|
| Saline vs LPS | Fatty acids | ARA | * | 1.827 | – | 1.854 |
| DHA | 2.033 | 1.590 | – | – | ||
| EPA | * | – | – | 1.791 | ||
| n-3 derived oxylipins | 5-HEPE | 2.049 | – | – | 5.626 | |
| PGD3 | ND | ND | – | 2.498 | ||
| PGE3 | – | ND | 3.256 | 4.217 | ||
| 10(S)-17(S)-DiHDoHE | ND | ND | – | 2.249 | ||
| 19,20-DiHoPE | 3.886 | 1.376 | 1.874 | 3.822 | ||
| TBXB3 | * | ND | 2.637 | 4.752 | ||
| Other oxylipins | 5,6 EET | – | – | – | 2.847 | |
| 11,12 EET | – | – | – | 1.843 | ||
| 14,15 EET | – | 1.890 | – | – | ||
| LTB4 | ND | 0.538 | – | * | ||
| LTD4 | ND | ND | – | 2.445 | ||
| n-acetyl leukotriene E4 | ND | 1.627 | * | ND | ||
| 5,6 DiHETrE | – | – | – | 1.744 | ||
| 8,9-DiHETrE | 2.170 | – | – | * | ||
| 11,12-DiHETrE | 2.167 | – | – | – | ||
| 14,15-DiHETrE | 1.943 | – | – | * | ||
| PGE2 | 1.958 | 2.449 | – | 2.039 | ||
| PGF2α | – | – | – | 1.777 | ||
| 8-iso-PGF2α | – | 1.778 | – | – | ||
| 13,14-dihydro-15-keto-PGE2 | 2.600 | – | – | 1.243 | ||
| 13,14-dihydro-15-keto-PGF2α | ND | 1.815 | – | – | ||
| 12-HHTrE | 0.201 | – | – | 2.252 | ||
| 5-HETE | 2.240 | – | – | 2.435 | ||
| 11-HETE | 0.561 | 1.887 | – | 1.925 | ||
| 12-HETE | – | 0.782 | – | – | ||
| 15-HETE | 0.433 | – | – | – | ||
| 20-HETE | ND | 2.399 | – | ND | ||
| TBXB2 | 0.175 | – | 2.560 | 2.277 | ||
| 9-HODE | 1.267 | – | 2.768 | 2.014 | ||
| 13-HODE | – | – | 2.086 | 1.206 | ||
| 9,10,13-TriHOME | 1.301 | * | – | – | ||
| Lipoxin A4 | ND | – | – | 2.372 | ||
Only statistically significant effects are listed, presented as fold-control values, calculated by comparing mean metabolite concentration from the saline to the LPS groups. Means were calculated from the different diet groups together for saline and LPS treated animals.
ND the compound was not detected in the particular matrix, and – indicates that no statistical significant differences were observed
* Interaction effect (see supplemental data for details)