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. 2012 Nov;140(5):481–493. doi: 10.1085/jgp.201210817

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© 2012 Labro et al.

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Figure 4. — C-type inactivation properties of Shaker and Kv1.2. (A) Ionic current recordings from oocytes expressing Shaker (black trace) or Kv1.2 channels (gray trace) evoked by depolarizing the membrane potential from a holding of −80 to 20 mV. Upon prolonged depolarization, both channels display C-type inactivation, which is characterized by a reduction in current amplitude. At the end of the pulse, Kv1.2 channels display only 25 ± 3% (n = 4) current reduction, whereas Shaker channels display 52 ± 2% current decrease (n = 4). (B) Time constants of the inactivation process in Shaker (black circles) and Kv1.2 channels (gray circles) obtained by fitting the reduction in current amplitude with a single exponential function. Note that in both channels, the kinetics are voltage independent. Error bars represent SEM.