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. 2012 Nov;140(5):481–493. doi: 10.1085/jgp.201210817

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© 2012 Labro et al.

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Figure 7. — Slowing in charge return of Ci-VSP sensing current I_s. (A, top) Current tracings showing I_s of Ci-VSP using the indicated activation protocol. The I_sOFF from a moderate 30-mV test pulse is shown as the red trace in the inset. Note the rapid slowing down in Is_OFF that accompanies the most positive depolarizations. (bottom) Current tracings are a superposition of I_sOFF at −50 mV upon 200-ms (black) and 1-s (red) depolarizations to 80 mV. Note the slowing in I_sOFF decay when depolarizations get prolonged. (B) Kinetics of activating I_sON (open triangles) obtained in WT Ci-VSP from different activation voltage pulses (similar to the protocol shown in A) and of deactivating I_sOFF obtained in WT Ci-VSP using 80-mV prepulses of the indicated durations from 200 ms to 5 s (colored symbols) and pulsing to different deactivation voltages. (C) The weighted time constant of I_sOFF decay measured at 10 mV is plotted as a function of the duration of the conditioning prepulse. The obtained curve was fitted to a single exponential function and yielded a time constant of τ = 530 ± 80 ms (n = 7). Error bars represent SEM.