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. 2012 Nov;140(5):495–511. doi: 10.1085/jgp.201210823

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© 2012 Goodchild et al.

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Figure 7. — Kinetic modeling of intracellular NMG⁺ binding can account for the observed slowing of Ig_OFF kinetics. (A) Schematic of the Markov model used to simulate gating currents. (B, left) Simulated gating currents with the depicted voltage protocols and a slowing factor θ of 9.4 as in the original ZHA model. (right) Normalized Q-V relationships calculated by integrating gating current for 11 ms after the depolarizing pulse (Q_on/Q_on(max)), repolarization (Q_off/Q_on(max)), or hyperpolarization after 50 ms at 0 mV (Q_off/Q_{on(0 mV)}). (C) Repeat of simulations in B, but with the removal of the slowing factor (θ = 1). (D) Repeat of simulations in B, but with the addition of 140 mM NMG⁺_i. Error bars represent SEM.