Table 2.

Consistency of the effects in the CHS and FHS cohorts of the SNPs significantly associated with AD in the Rotterdam study

					RS1				CHS				FHS
Gene	SNP	Chr	Position	Coded allele	Freq controls	OR	95% CI	P- value	Freq controls	OR	95% CI	P- value	Freq controls	OR	95% CI	P- value
HSPA12B	rs3899452	20	3775265	C	0.13	1.49	1.22-1.85	0.0002	0.14	0.90	0.70-1.16	0.413	0.14	0.63	0.30-1.31	0.216
HSPA5	rs13294021	9	127108209	G	0.51	1.21	1.05-1.39	0.008	0.53	0.93	0.80-1.07	0.297	0.52	0.84	0.62-1.15	0.278
PFDN2	rs12118313	1	159304603	C	0.22	1.37	1.16-1.61	0.0001	0.22	1.01	0.84-1.22	0.891	0.21	1.06	0.70-1.61	0.770
BAG2_1	rs7760349	6	57220087	A	0.45	1.28	1.11-1.47	0.0007	0.45	0.97	0.83-1.12	0.658	0.44	1.09	0.78-1.53	0.602
BAG2_2	rs13213618	6	57229922	G	0.17	1.37	1.15-1.64	0.0005	0.16	1.07	0.87-1.33	0.520	0.18	0.76	0.48-1.22	0.261
DNAJC14	rs1463592	12	54543559	A	0.22	1.28	1.09-1.52	0.003	0.18	1.06	0.87-1.29	0.556	0.22	1.27	0.88-1.84	0.208
DNAJC17	rs7915	15	38893777	C	0.37	1.24	1.08-1.43	0.003	0.35	0.83	0.71-0.96	0.013	0.37	0.81	0.56-1.15	0.230
DNAJA4	rs8027394	15	76404968	C	0.70	1.33	1.14-1.57	0.0005	0.67	0.99	0.85-1.16	0.892	0.66	1.02	0.73-1.41	0.921
DNAJC28	rs7280365	21	33874453	G	0.62	1.28	1.10-1.49	0.001	0.64	1.01	0.86-1.18	0.953	0.61	0.95	0.67-1.37	0.800

RS1: Rotterdam study; CHS: Cardiovascular Health Study; FHS: Framingham Heart Study; Chr: chromosome; Freq: frequency; OR: Odds Ratio; 95% CI: 95% Confidence Interval; Bold: The results for this gene are consistent across populations, with all ORs in the same direction.