Table 4.

Enriched biological process GO^a terms in protein families born at the LCA^b of the three major metazoan groups and the LCA of metazoans

Groups	GO terms	Description	P-value
Families born at the LCA of metazoans
	GO:0006355	regulation of transcription, DNA-dependent	1.29E-106
	GO:0006836	neurotransmitter transport	7.59E-11
	GO:0007275	multicellular organismal development	1.25E-09
	GO:0006637	acyl-CoA metabolic process	4.33E-08
	GO:0007186	G-protein coupled receptor protein signaling pathway	1.35E-07
	GO:0007040	lysosome organization and biogenesis	4.78E-06
	GO:0007223	Wnt receptor signaling pathway, calcium modulating pathway	4.78E-06
	GO:0030704	vitelline membrane formation	6.47E-06
	GO:0006508	proteolysis	1.48E-05
	GO:0006094	gluconeogenesis	1.90E-05
	GO:0006665	sphingolipid metabolic process	3.24E-05
	GO:0007179	transforming growth factor beta receptor signaling pathway	3.24E-05
	GO:0006869	lipid transport	5.22E-05
	GO:0045449	regulation of transcription	9.33E-05
	GO:0006835	dicarboxylic acid transport	3.50E-04
	GO:0007600	sensory perception	3.50E-04
	GO:0045087	innate immune response	8.15E-04
	GO:0007026	negative regulation of microtubule depolymerization	9.14E-04
Families born at the LCA of nematodes
	GO:0051085	chaperone cofactor-dependent protein folding	9.14E-04
	GO:0007186	G-protein coupled receptor protein signaling pathway	3.54E-116
	GO:0016998	cell wall catabolic process	7.49E-06
	GO:0005992	trehalose biosynthetic process	2.37E-05
	GO:0006812	cation transport	2.98E-04
Families born at the LCA of arthropods
	GO:0006030	chitin metabolic process	1.08E-22
	GO:0006814	sodium ion transport	2.32E-18
	GO:0006950	response to stress	2.02E-11
	GO:0007608	sensory perception of smell	4.74E-11
Families born at the LCA of vertebrates
	GO:0007186	G-protein coupled receptor protein signaling pathway	7.41E-155
	GO:0006955	immune response	1.29E-39
	GO:0001558	regulation of cell growth	2.57E-10
	GO:0007154	cell communication	4.19E-10
	GO:0050909	sensory perception of taste	4.88E-10
	GO:0045087	innate immune response	1.04E-09
	GO:0015671	oxygen transport	7.68E-09
	GO:0048468	cell development	1.03E-08
	GO:0006691	leukotriene metabolic process	7.08E-08
	GO:0042981	regulation of apoptosis	1.99E-07
	GO:0019882	antigen processing and presentation	3.04E-07
	GO:0009395	phospholipid catabolic process	3.60E-06
	GO:0006915	apoptosis	5.43E-06
	GO:0016049	cell growth	2.51E-05
	GO:0006486	protein amino acid glycosylation	3.09E-05
	GO:0006952	defense response	5.80E-05
	GO:0006071	glycerol metabolic process	8.96E-05
	GO:0009607	response to biotic stimulus	2.40E-04
	GO:0030178	negative regulation of Wnt receptor signaling pathway	2.54E-04
	GO:0043065	positive regulation of apoptosis	2.54E-04

^a GO, Gene Onthology; ^b LCA, Last Common Ancestor.