Table 5.

Enriched biological process GO^a terms in protein families died at the LCAs^b of three major metazoan groups

Groups	GO terms	Description	P-value
Families died at the LCA of arthropods
	GO:0006637	acyl-CoA metabolic process	1.75E-18
	GO:0030704	vitelline membrane formation	9.07E-18
	GO:0006869	lipid transport	2.08E-09
	GO:0006814	sodium ion transport	1.81E-08
	GO:0045454	cell redox homeostasis	2.84E-08
	GO:0006555	methionine metabolic process	4.00E-04
	GO:0006952	defense response	5.87E-04
Families died at the LCA of nematodes
	GO:0006308	DNA catabolic process	8.53E-08
	GO:0006281	DNA repair	7.29E-05
	GO:0035023	regulation of Rho protein signal transduction	2.10E-04
	GO:0006779	porphyrin biosynthetic process	2.65E-04
	GO:0006493	protein amino acid O-linked glycosylation	2.96E-04
	GO:0017000	antibiotic biosynthetic process	8.77E-04
Families died at the LCA of vertebrates
	GO:0007186	G-protein coupled receptor protein signaling pathway	3.00E-12
	GO:0016539	intein-mediated protein splicing	1.00E-07
	GO:0007154	cell communication	3.28E-05
	GO:0006030	chitin metabolic process	9.21E-05
	GO:0006097	glyoxylate cycle	1.83E-04
	GO:0007275	multicellular organismal development	1.98E-04

^a GO, Gene Onthology; ^b LCA, Last Common Ancestor.