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. 2012 Oct 29;7(10):e48282. doi: 10.1371/journal.pone.0048282

Figure 2. Disruption of translation extends longevity in C. elegans.

Figure 2

The gene inactivations found to extend lifespan by the greatest percentage function in translation. T23D8.3 is the C. elegans ortholog of human LTV1, which is required for the nuclear export and processing f the 40S ribosomal subunit. The ribosomal protein subunit rps-14 directly participates in the 40S ribosome and is required for translation. Mean lifespan extension following postdevelopmental inactivation of these genes in an enhanced RNAi strain, eri-1, is 26% for the LTV1 ortholog (dashed line) and 16.6% for rps-14 (dotted line) in comparison to an empty vector RNAi control (solid line). The lifespan extension phenotypes of these genes are consistent with the phenotypes of other translation genes in our screen, including rps-12 and 3 RNA polymerases (Tables 1 and 2).