Table 2. First-order interactors of LAGs in the HLN regulate lifespan in C. elegans.
| Gene | Common name | Lifespan (%Δ mean)a | Lifespan (%Δ max)a | Function |
| C03C10.3b | rnr-2 | 14.2 | 21.7 | DNA biosynthesis |
| R02D3.3 | R02D3.3 | 13.0 | 21.7 | RNA polymerase II |
| F10B5.6 | emb-27 | 10.5 | 8.7 | Cell division |
| F29G9.3 | aps-1 | 7.9 | 0.0 | Adaptin |
| T09B4.10 | chn-1 | 7.1 | 8.7 | Ubiquitin ligase |
| F26F4.11b | rpb-8 | 6.4 | 0.0 | RNA polymerase II |
| F28D9.1 | rsr-1 | 6.1 | 0.0 | Splicing |
| F18A1.5 | rpa-1 | 5.1 | 21.7 | DNA replication |
| C01H6.5 | nhr-23 | 4.9 | 8.7 | Molting |
| Y40B1A.4 | sptf-3 | −22.9 | −37.0 | Transcription factor |
| ZK1058.2 | pat-3 | −28.1 | −50.0 | Integrin |
| C52E4.4 | rpt-1 | −28.4 | −50.0 | Proteasome |
| F26H9.6 | rab-5 | −38.0 | −50.0 | Endocytosis |
| D1014.3 | snap-1 | −39.9 | −50.0 | Vesicle fusion |
| K02D10.5 | K02D10.5 | −48.6 | −72.0 | SNARE complex |
a
%Δ mean and %Δ maximum lifespan (last quartile) were calculated in relation to control.
b
Shared genes in WLN and HLN.