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. 2012 Aug 29;12:136. doi: 10.1186/1471-2431-12-136

Table 4.

Most commonly prescribed medicines (received by >10 patients) containing known to be harmful or potentially harmful excipients

Rank Active substance, drug formulation No of prescriptions Potentially harmful or known to be harmful excipients
1
Gentamicin, inj solution
200
Parabens, sodium metabisulphite
2
Simeticone, oral suspension
108
Sodium benzoate, saccharin sodium, silicium dioxide, sodium cyclamate, sorbic acid
3
Heparin, inj solution
86
Benzyl alcohol, parabens
4
Laurilsulphate + Sorbitol + Sodium citrate, rectal solution
60
Sorbic acid
5
Salbutamol, nebulisation solution
54
Benzalkonium chloride, propylene glycol
6
Dobutamine, inj solution
45
Sodium metabisulphite
7
Epinephrine, inj solution
36
Sodium metabisulphite
8
Iron, oral solution
32
Parabens, saccharin sodium
9
Budesonide, nebulisation solution
31
Polysorbate 80, disodiumedetate
10
Chloramphenicol, opthalmic solution
29
Benzalkonium chloride, polysorbate 80, borax, boric acid
11
Caffeine, solution
29
Sodium benzoate
12
Phenobarbital, tablet
29
Silicium dioxide, gelatin
13
Paracetamol, suppository
29
Disodium hydrogen phosphate
14
Piperacillin + tazobactam, inj solution
25
Disodium edetate
15
Paracetamol, inj solution
24
Disodium hydrogen phosphate
16
Hydrocortisone, inj solution
23
Benzyl alcohol, disodium hydrogen phosphate
17
Epoetin beta, inj solution
22
Disodium hydrogen phosphate, glycine, calcium chloride dihydrate, leucine,
18
Ibuprofen, inj solution
21
Trometamol
19
Hyoscine butylbromide, tablet
20
Silicium dioxide
20
Spironolactone, tablet
18
Silicium dioxide
21
Zidovudine, oral solution
17
Sodium benzoate, saccharin sodium
22
Fusidic acid, ophthalmic solution
16
Benzalkonium chloride, disodium edetate
23
Morphine, inj solution
14
Sodium metabisulphite
24
Phenobarbital, inj solution
13
Benzyl alcohol, propylene glycol
25
Heparin sodium, topical gel
12
Parabens, ethanol, trietanolamine,
26 Insulin, inj solution 11 Cresol

Inj - injection.