Table 2.
MicroRNA profiling of alpha-synuclein containing exosomes from primary cortical neuron media
| miRNAs | function | remarks | Key citations |
|---|---|---|---|
| 27a |
activating the expression of P-glycoprotein |
present in exosomes |
[39][55] |
| 28 |
inhibitor of thrombopoietin receptor translation |
present in exosomes |
[39][56] |
| 34a |
suppression of cell proliferation through modulation of the E2F signaling pathway |
- |
[57] |
| 106b |
modulation of TGFβ signaling in tumors |
present in exosomes |
[39][58] |
| 184 |
Block of NFAT1 protein expression |
present in exosomes |
[40,43] |
| 185 |
Inducion of cell cycle arrest in lung cancer cell lines |
present in exosomes |
[40,59] |
| 192 |
affects cellular proliferation through the p53-miRNA circuit |
present in exosomes |
[39][60] |
| 199b |
Regulation of protein phosphatase 2A inhibitor) in human choriocarcinoma |
- |
[61] |
| 302b* |
regulatory mechanism in tuning stem cell properties |
- |
[62] |
| 373* |
Involvement in tumor migration and invasion |
present in exosomes |
[39,46] |
| 422b |
- |
present in exosomes |
[40] |
| 431 |
- |
CNS specific miRNA |
[47,50] |
| 448 |
- |
- |
[63] |
| 455 |
- |
- |
[51] |
| 487a |
Role in angiogenesis and cell aging |
- |
[52] |
| 491 |
decreases cell viability by induction of apoptosis |
- |
[64] |
| 493-3p |
- |
- |
[54] |
| 518* |
Predicted to be involved in Huntington’s disease |
- |
[54,65] |
| 522 |
- |
present in exosomes |
[39] |
| 526a |
- |
present in exosomes |
[39] |
| 526b | - |