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. 2012 Oct 29;7(10):e48126. doi: 10.1371/journal.pone.0048126

Figure 6. Molecular requirements for splenic T1IFN transcriptional induction.

Figure 6

(A) Tlr9 and Myd88 are required for full transcriptional induction of T1IFNs in spleens of P. chabaudi-infected C57Bl/6 mice. Grey dots represent the means of independent experiments using 4–6 total mice, with T1IFN fold mRNA induction in knockout mice represented as a percentage of induction in wild type animals. Black bars represent means; asterisks represent p<0.05 as compared to wild type induction in a two-tailed Student’s t-test assuming unequal variances. (B) Irf7 is required for full T1IFN induction, and Irf3 is required for full Ifna but not Ifnb induction. (C) Ifnar1 is required for full Ifna induction but dispensable for Ifnb induction, whereas Ifngr1 is dispensable for all T1IFN induction.