Figure 7. Mice lacking RPMs exhibit wild type infection kinetics.

(A) Parasitemia courses in 129Sv SpiC^+/− (n = 4) and SpiC^−/− (n = 5) mice are represented as geometric means with standard deviations and Mann-Whitney p-value. (B) Ly6c^lo monocyte (CD11b⁺ F4/80⁺ Ly6g⁻ SSC^lo Ly6c^lo) frequencies in blood and spleen of 129Sv SpiC^+/− (white bars) and SpiC^−/− mice (black bars) during the course of infection. Days depicted in blue and orange represent a 1.5-fold decrease or increase, respectively, in Ly6c^lo monocyte frequencies in blood and spleen of mice infected with P. chabaudi. (C) Ly6c^lo monocyte frequencies on day 12 post-infection. Means are presented with standard errors; p-values represent a two-tailed t-test assuming unequal variances. Data represent three independent experiments (n = 6–7 mice per group total).