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. 2012 Oct 29;7(10):e48028. doi: 10.1371/journal.pone.0048028

Table 3. Cardiac gene processes inhibited by Tbx5, Gata4 and Myocd.

Gene ontology name T G M T+G G+M T+M T+G+M
Cardiac (permute P value)
Wnt receptor signaling pathway 1.0 0.196 0.018* N N 0.097 0.018*
Heart development 0.796 N 0.014* N N 0.029* N
Myoblast differentiation N N N 0.026* N N N
Sarcomere 0* 0.004* N 0.006* N N N
Myofibril 0* 0.008* N 0.015* N N N
Skeletal muscle fiber development N N N 0.023* N N N
Contractile fiber 0* 0.004* N 0.013* N N N
Structural constituent of cytoskeleton 0.018* 0.07 N 0.019* N N N
Muscle development 0.001* 0.134 0.742 0.009* 0.164 0.514 0.793
Actin cytoskeleton organization and biogenesis 0.006* 0.056 0.617 0.002* 1.0 0.396 0.045*
Cytoskeletal protein binding 0.027* 0.067 0.45 0.013* 0.854 0.69 0.25
Muscle contraction 0.001* 0.003* 0.052 0.004* 0.017* 0.01* 0.189
Circulation 0.018* 0.077 N 0.393 0.104 N 0.483
*

GO terms with permute p<0.05 and a nested gene change number ≥4 were considered to be significantly inhibited. GOs with a nested gene change number <4 were shown as “N”. GO terms that were both activated and inhibited were excluded. T, Tbx5; G, Gata4; M, Myocd.