Table 3. Cardiac gene processes inhibited by Tbx5, Gata4 and Myocd.
Gene ontology name | T | G | M | T+G | G+M | T+M | T+G+M |
Cardiac | (permute P value) | ||||||
Wnt receptor signaling pathway | 1.0 | 0.196 | 0.018* | N | N | 0.097 | 0.018* |
Heart development | 0.796 | N | 0.014* | N | N | 0.029* | N |
Myoblast differentiation | N | N | N | 0.026* | N | N | N |
Sarcomere | 0* | 0.004* | N | 0.006* | N | N | N |
Myofibril | 0* | 0.008* | N | 0.015* | N | N | N |
Skeletal muscle fiber development | N | N | N | 0.023* | N | N | N |
Contractile fiber | 0* | 0.004* | N | 0.013* | N | N | N |
Structural constituent of cytoskeleton | 0.018* | 0.07 | N | 0.019* | N | N | N |
Muscle development | 0.001* | 0.134 | 0.742 | 0.009* | 0.164 | 0.514 | 0.793 |
Actin cytoskeleton organization and biogenesis | 0.006* | 0.056 | 0.617 | 0.002* | 1.0 | 0.396 | 0.045* |
Cytoskeletal protein binding | 0.027* | 0.067 | 0.45 | 0.013* | 0.854 | 0.69 | 0.25 |
Muscle contraction | 0.001* | 0.003* | 0.052 | 0.004* | 0.017* | 0.01* | 0.189 |
Circulation | 0.018* | 0.077 | N | 0.393 | 0.104 | N | 0.483 |
GO terms with permute p<0.05 and a nested gene change number ≥4 were considered to be significantly inhibited. GOs with a nested gene change number <4 were shown as “N”. GO terms that were both activated and inhibited were excluded. T, Tbx5; G, Gata4; M, Myocd.