. 2012 Oct 29;7(10):e48028. doi: 10.1371/journal.pone.0048028

Table 4. Non-cardiac gene processes inhibited by Tbx5, Gata4 and Myocd.

Gene ontology name	T	G	M	T+G	G+M	T+M	T+G+M
Non-cardiac	(permute P value)
Embryonic limb morphogenesis	N	N	N	N	N	N	0.017^*
Embryonic appendage morphogenesis	N	N	N	N	N	N	0.017^*
Cartilage development	0^*	N	N	0^*	0^*	0^*	0.001^*
Blood coagulation	0.001^*	0^*	0.016^*	0.016^*	0.024^*	N	0.003^*
Tube morphogenesis	0.077	0.049^*	N	0.06	N	0.006^*	0.006^*
Epidermis development	0.062	0.002^*	0.013^*	0^*	0^*	0.006^*	0.008^*
Axonogenesis	0.081	0.001^*	0^*	0.004^*	0.003^*	0^*	0.002^*
Ossification	0.777	0.139	0.105	0.161	0.195	0.162	0.029^*
Central nervous system development	0.055	N	0.189	0.398	0.152	0.026^*	0.013^*
Ectoderm development	0.171	0.002^*	0.024^*	0.001^*	0^*	0.001^*	0.002^*
Embryonic development	0.074	0.05	0.018^*	0.029^*	0.087	0.002^*	0.005^*
Neuron development	0.417	0.006^*	0^*	0.034^*	0.021^*	0^*	0.011^*
Blood vessel development	0.11	0.47	0.018^*	0.41	0.028^*	0.004^*	0.007^*
Skeletal development	0.006^*	0^*	0^*	N	0^*	0^*	0^*
Development	0^*	0^*	0^*	0^*	0^*	0^*	0^*
Humoral immune response	N	N	N	0.563	N	N	0.011^*
Meiotic cell cycle	0.521	0.007^*	N	0.008^*	0.007^*	N	N
Reproduction	0.085	0.853	0.003^*	0.134	0.037^*	0.052	0.449
Germ cell development	0.006^*	N	0.008^*	N	N	N	N
Eye development	0.016^*	N	0.009^*	0.265	N	N	N
Gonad development	N	N	0.012^*	0.065	N	N	N
T cell activation	0.063	0.12	0.033^*	0.527	0.062	0.025^*	0.094
Female gamete generation	0.002^*	N	N	0.058	N	N	N

GO terms with permute p<0.05 and a nested gene change number ≥4 were considered to be significantly inhibited. GOs with a nested gene change number <4 were shown as “N”. GO terms that were both activated and inhibited were excluded. T, Tbx5; G, Gata4; M, Myocd.