Table 3.
Multivariable Associations of Leptin with Change in Cognitive Function Among Males From Linear Mixed Effects Models, Stratified by Waist Circumference, SALSA, 1998–2008.
| Waist circumference | ||||
|---|---|---|---|---|
|
| ||||
| Waist ≤35 (N=371; 60.4%) | Waist >35 (N=243; 39.6%) | |||
|
| ||||
| Model 1 β (SE) | Model 2 β (SE) | Model 1 β (SE) | Model 2 β (SE) | |
| Outcome: Log 3MSE errors a | ||||
| Intercept | 2.43 (0.12)* | 2.70 (0.14)* | 2.20 (0.22)* | 2.34 (0.21)* |
| Age | 0.02 (0.01) | 0.03 (0.01)* | −0.05 (0.03) | −0.03 (0.02) |
| Log Leptin | −0.11 (0.06) | −0.05 (0.06) | −0.04 (0.09) | 0.08 (0.08) |
| Log Leptin x Age | −0.01 (0.01) | −0.01 (0.01)* | 0.02 (0.01) | 0.01 (0.01) |
| AIC | 3833.9 | 3505.2 | 2501.0 | 2347.1 |
| Outcome: SEVLT a | ||||
| Intercept | 7.79 (0.36)* | 7.27 (0.49)* | 8.47 (0.63)* | 8.31 (0.69)* |
| Age | −0.15 (0.04)* | −0.17 (0.04)* | −0.16 (0.08) | −0.15 (0.08) |
| Log Leptin | 0.13 (0.19) | 0.15 (0.20) | −0.12 (0.26) | −0.39 (0.26) |
| Log Leptin x Age | 0.04 (0.02) | 0.06 (0.02)* | 0.04 (0.03) | 0.04 (0.03) |
| AIC | 7477.8 | 7090.3 | 4784.3 | 4635.6 |
Abbreviations: 3MSE, Modified Mini Mental State Exam; SALSA, Sacramento Area Latino Study on Aging; SEVLT, Spanish English Verbal Learning Test.
*
P value <0.05.
a
Model 1 is unadjusted; Model 2 additionally adjusts for nativity, education, income, type-2 diabetes, and HOMA-IR