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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Mol Genet Metab. 2012 Jul 28;107(3):276–280. doi: 10.1016/j.ymgme.2012.07.020

Fig. 1.

Fig. 1

The lysosomal enzyme-targeting pathway. In a first step, GNPTAB/G transfers GlcNAc-1-phosphate from UDP-GlcNAc onto the terminal mannose of N-linked oligosaccharides. In a second step, the GlcNAc residue is cleaved off by NAGPA, thereby uncovering the mannose-6-phosphate targeting signal.