Table 3.

Association of SNPs in Moderate to High LD with the top discovery SNPs (R2>0.25) in an independent Dominican cohort of 301

Phenotype	Gene	Discovery SNP	Follow- Up SNP	Function	Position (MB)	D′	R2	Minor Allele	MAF	Odds Ratio (95% CI)†	P-value*
										1.65
Thick	VWF	rs216809	rs216887	intron	5.969	0.89	0.44	C	0.47	(1.03,2.64)	3.62E-02
										1.77
			rs216888	intron	5.969	0.86	0.42	G	0.47	(1.09,2.88)	2.20E-02
										1.84
			rs216891	intron	5.970	0.64	0.26	G	0.47	(1.15,2.94)	1.06E-02
										1.52
			rs216896	intron	5.971	0.86	0.42	T	0.47	(0.96,2.41)	7.53E-02
										0.59
			rs216903	intron	5.976	0.83	0.25	T	0.41	(0.36,0.95)	2.98E-02
										1.54
			rs216904	intron	5.976	0.91	0.80	C	0.33	(0.95,2.48)	7.66E-02
										1.91
			rs216905	intron	5.977	0.95	0.27	T	0.15	(1.07,3.61)	2.99E-02
										1.33
			rs216801	intron	5.979	0.94	0.84	A	0.35	(0.82,2.14)	2.44E-01
										0.93
Irregular	THBS1	rs1478604	rs11070217	upstream	37.609	0.68	0.36	C	0.43	(0.56,1.55)	7.80E-01
										1.29
			rs2618162	upstream	37.655	0.99	0.97	C	0.48	(0.76,2.19)	3.41E-01
										1.39
			rs1134485	intron	37.667	1.00	0.54	T	0.34	(0.80,2.42)	2.43E-01
										1.82
			rs2228261	CDS	37.668	1.00	0.39	T	0.27	(1.03,3.22)	3.96E-02

^*adjusted for age, sex, smoking, hypertension, dyslipidemia, diabetes, and PCA1

^†Odds ratio is measuring the risk of the minor allele

MAF = Minor Allele Frequency

D` and R2 are the measures of LD between the SNP from the discovery analysis and the SNP from the follow-up analysis