Table 4.

Associated Haplotypes in (p≤0.01) the Discovery Sample

Phenotype	Gene	Haplotype Candidate from MDR	Freq in Controls	Freq in Cases	Coeff	SE	P-Value*
Plaque	SERPINE1	SNP1=rs6092; SNP2=rs2227631; SNP3=rs1050813
		ggg (ref)	0.49	0.50
		gaa	0.03	0.09	1.46	0.52	5.28E-03
Thick	vWF	SNP1=rs980130; SNP2=rs216809
		gc (ref)	0.47	0.63
		ga	0.33	0.15	−1.074	0.38	5.21E-03
Irregular	vWF	SNP1=rs4764478; SNP2=rs2885517; SNP3=rs12580343
		tgg (ref)	0.3	0.22
		agg	0.03	0.22	2.46	0.91	7.68E-03

^*p-value adjusted tor age, sex, smoking, hypertension, dyshpidemia, and diabetes - from haplo.glm

Coeff = estimated regression coefficient.

Note: e^coeff = odds ratio of this haplotype compared to the reference (ref) haplotype

Haplotypes with a frequency < 10 were grouped as ‘Rare Haplotypes’

Note that each haplotype was compared to the most common haplotype as noted by (ref) for each gene, however only haplotypes with p ≤ 0.0125 are presented in this table. Full results are in Supplementary Table S3.