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. Author manuscript; available in PMC: 2012 Oct 30.
Published in final edited form as: Cell Rep. 2012 Sep 27;2(4):799–806. doi: 10.1016/j.celrep.2012.08.025

Figure 3. Gems are lost in HeLa cells transfected with ALS-causing R495X FUS mutation.

Figure 3

(A) Representative images showing the expression of FLAG tagged FUS or FUS R495X in HeLa cells (red). Gems were detected using SMN antibodies (green in nucleus). Scale bar, 20 μm. (B) Quantitation of Gem levels in HeLa cells expressing the indicated proteins. The mean and standard deviation of Gem number per cell were calculated from three independent experiments. At least 100 cells were observed in each experiment. P-values were calculated by comparison with three controls. * indicates p < 0.01, Student’s t test.