Table 1.
Details of TET2 somatic mutations found in normal elderly individuals (n=10)1.
Nucleotide substitution | Amino-acid substitution | Chromosome | Position |
---|---|---|---|
c.286_298delCGCACAGTTAGTG | p.Arg96Asnfs*12 | 4 | 106,155,385 |
c.1330delA | p.Thr444Hisfs*6 | 4 | 106,156,429 |
c.1348delA | p.Lys450Lysfs*2 | 4 | 106,156,447 |
c.1547delC | p.Pro516Hisfs*16 | 4 | 106,156,646 |
c.1630C>T | p.Arg544* | 4 | 106,156,729 |
c.3311_3312insAT | p.Phe1104Leufs*3 | 4 | 106,158,411 |
c.3991A>C | p.Thr1331Pro | 4 | 106,182,952 |
c.5200delA | p.Met1734Leufs*11 | 4 | 106,196,867 |
c.5575insT | p.Ile1859tyrfs*16 | 4 | 106,197,239 |
c.5725G>T | p.Glu1909* | 4 | 106,197,392 |
Reference sequence used to annotate TET2 mutations was NM_001127208.