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. Author manuscript; available in PMC: 2013 Nov 1.

Published in final edited form as: J Pediatr Gastroenterol Nutr. 2012 Nov;55(5):567–573. doi: 10.1097/MPG.0b013e31826eb0cf

A: Presence of clinical characteristics or history of complications of PHT at enrollment. The percentage of the BA subjects who reported ascites, esophageal variceal bleeding (EV Bleed), hepatopulmonary syndrome (HPS), splenomegaly [spleen tip > 2 cm below the costal margin], thrombocytopenia [Platelet count (plt) < 150k] or both (Spleen + Plt) are noted. Subjects could have more than one characteristic or complication so that the total is greater than 100%.

B: Venn diagram of the factors determining presence of Definite PHT. The factor associated with definite PHT is represented by each ellipse and is described by the text next to the ellipse. The interrelationship of the features is indicated by the overlap of the ellipses and the number with the overlapping sections. For example, following the left-most ellipse of Ascites, only 4 of the 14 reported ascites alone, while 1 each reported ascites+ EV bleed and ascites + HPS + EV bleed, while none of the 8 subjects with HPS had HPS + ascites. In 56 subjects PHT was absent and in 27 it was possible (not shown). Sizes of the ellipses do not correlate with the number of subjects. EV = esophagogastric variceal hemorrhage; HPS = hepatopulmonary syndrome.

A: Presence of clinical characteristics or history of complications of PHT at enrollment. The percentage of the BA subjects who reported ascites, esophageal variceal bleeding (EV Bleed), hepatopulmonary syndrome (HPS), splenomegaly [spleen tip > 2 cm below the costal margin], thrombocytopenia [Platelet count (plt) < 150k] or both (Spleen + Plt) are noted. Subjects could have more than one characteristic or complication so that the total is greater than 100%.

B: Venn diagram of the factors determining presence of Definite PHT. The factor associated with definite PHT is represented by each ellipse and is described by the text next to the ellipse. The interrelationship of the features is indicated by the overlap of the ellipses and the number with the overlapping sections. For example, following the left-most ellipse of Ascites, only 4 of the 14 reported ascites alone, while 1 each reported ascites+ EV bleed and ascites + HPS + EV bleed, while none of the 8 subjects with HPS had HPS + ascites. In 56 subjects PHT was absent and in 27 it was possible (not shown). Sizes of the ellipses do not correlate with the number of subjects. EV = esophagogastric variceal hemorrhage; HPS = hepatopulmonary syndrome.