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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Mol Genet Metab. 2012 Sep 17;107(3):315–321. doi: 10.1016/j.ymgme.2012.09.016

Figure 3. Effect of the two treatment arms on aspartate and alanine aminotransferases.

Figure 3

A. Treatment with the high-dose of arginine leads to increase in plasma AST and ALT. The increased AST levels on HDA arm were statistically significant (P=0.002). Each data-point on the graph depicts the mean of two values measured on days 6 and 7. B. Linear regression using GEE and Spearman rank correlation found a significant relationship between plasma argininosuccinate and AST (partial η2 = 0.635, P<0.001; r2=0.568) and ALT levels (partial η2 = 0.794, P<0.001; r2=0.474).