Figure 3.

The murine model ECM is associated with vascular collapse. Mice were infected with P. berghei-ANKA strain. A–C: In mice with ECM, collapse of a major vessel and branches (arrows, B) is observed on day 6 of infection. D–F: There is collapse of two branches (arrow, E) of a vessel and microhemorrhages (circles, F). Vessel collapse occurred between two observations on the same day (day 6 of infection); the mouse developed clinical CM during the interval between observations. G–I: Collapse of virtually the entire vascular network is observed on day 6 of infection. J–L: Collapse of the vascular network on day 6 after a major hemorrhage (arrows, J and K) on days 4 and 5 of infection.

Reprinted from Cabrales et al¹⁴ with permission of Elsevier.