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Algorithm used for the functional classification of neural network-predicted TISs as either “annotated TIS,” “N-terminal protein extension,” “upstream ORF” (uORF),” or “CDS-overlapping uORF.” The respective AUG or non-cognate codon was searched for in a ±3-bp window around the merged positive TIS signal emitted by the neural network. For each transcript, the depicted algorithm is applied until no further network-predicted TISs are available for classification.
