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. 2012 Nov;22(11):2250–2261. doi: 10.1101/gr.136572.111

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© 2012, Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported License), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 2. — Closed chains of breakage and rejoining (CCBRs). (A) In an idealized version of a CCBR, no chromosomal material is lost or gained. (B) Actual CCBRs may involve small loss or gain of chromosomal material. For instance, the A₂→A₃ and C₂→C₃ sections of chromosomes A and C appear to have been lost, and the B₂→B₃ section of chromosome B appears to have been duplicated. (C) The breakpoint graph for the CCBR in B showing (A₁, A₄) and (C₁, C₄) loss edges and a (B₂, B₃) gain edge.