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. Author manuscript; available in PMC: 2012 Oct 30.
Published in final edited form as: Gene Ther. 2010 Apr 29;17(9):1098–1104. doi: 10.1038/gt.2010.57

Figure 6. Systemic injection of an HDAC6 inhibitor increases lung gene transfer without ventilation.

Figure 6

NCT-10b (100 μl of 200 μM) or DMSO vehicle (100 μl) was injected via the tail vein of mice. Four hours later, 50 μg of pCMV-lacZ-DTS were instilled into the lungs via an endotracheal tube and electroporated within 60 seconds of DNA delivery without any subsequent mechanical ventilation. Gene expression was measured 2 days later (n = 5).