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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Dev Biol. 2012 Sep 15;372(1):68–80. doi: 10.1016/j.ydbio.2012.09.002

Fig. 1. Conserved 5′ TF biinding sites in the Pou4f3 gene.

Fig. 1

A region that is conserved across four mammalian species is located 8.2-8.5 kb 5′ to the ATG of Pou4f3 in the mouse, where it supports ATOH1 binding (Masuda et al., 2011). Clustered E-boxes (CANNTG) are conserved at this site, including two of a type that is activated by ATOH1 (red boxes) (Klisch et al., 2011). The E-boxes are located in close proximity to conserved binding motifs for GATA and SP1.