Table 1.
Demographic and clinical characteristics of patients with severe sepsis according to outcome.
| Variable | All patients (n = 184) |
Survivors (n = 89, 48.4%) |
Nonsurvivors (n = 95, 51.6%) |
P value |
|---|---|---|---|---|
| Male, n (%) | 122 (66.3) | 56 (63.0) | 66 (69.5) | 0.34 |
| Female, n (%) | 62 (33.7) | 33 (37.0) | 29 (30.5) | |
| Age, mean (SD) | 57.1 (17.9) | 53.7 (18.3) | 60.3 (17.1) | 0.01 |
| Hospital stay, days, median (Q1–Q3) | 13 (6–20) | 18 (13.5–28) | 6 (4–12) | <0.001 |
| Number of comorbidities, n (%) | ||||
| 0 | 48 (26.1) | 30 (33.7) | 18 (18.9) | 0.02 |
| 1 | 76 (41.3) | 33 (37.1) | 43 (45.3) | |
| 2 | 42 (22.8) | 22 (24.7) | 20 (21.1) | |
| ≥3 | 18 (9.8) | 4 (4.5) | 14 (14.7) | |
| Comorbidities | ||||
| Chronic heart failure | 65 (35.3) | 22 (24.7) | 43 (45.3) | 0.004 |
| Diabetes mellitus | 38 (20.7) | 18 (20.2) | 20 (21.1) | 0.89 |
| Hemiplegic stroke | 28 (15.2) | 13 (14.6) | 15 (15.8) | 0.82 |
| Chronic respiratory failure | 22 (12.0) | 3 (3.4) | 19 (20.0) | 0.001 |
| Chronic alcoholism | 19 (10.3) | 11 (12.4) | 8 (8.4) | 0.38 |
| Metastatic cancer | 14 (7.6) | 8 (9.0) | 6 (6.3) | 0.49 |
| Chronic renal failure | 12 (6.5) | 4 (4.5) | 8 (8.4) | 0.28 |
| Chronic liver failure | 12 (6.5) | 7 (7.9) | 5 (5.3) | 0.47 |
| SAPS II score, median (Q1–Q3) | 35 (21–53) | 30 (18–37) | 43 (25–64) | <0.001 |
| Site of infection, n (%) | ||||
| Lower respiratory tract | 121 (65.8) | 56 (62.9) | 65 (68.4) | 0.17 |
| Meningitis Soft tissue |
17 (9.2) 15 (8.1) |
8 (9.0) 6 (6.7) |
9 (9.5) 9 (9.5) |
|
| Urinary tract | 10 (5.4) | 9 (10.1) | 1 (1.0) | |
| Abdominal (nonsurgical) | 6 (3.3) | 2 (2.3) | 4 (4.2) | |
| Endocarditis | 9 (4.9) | 4 (4.5) | 5 (5.3) | |
| Unknown | 6 (3.3) | 4 (4.5) | 2 (2.1) | |
| Number of failed organs, n (%) | ||||
| 1 | 61 (33.2) | 45 (50.6) | 16 (16.8) | <0.001 |
| 2 | 53 (28.8) | 25 (28.1) | 28 (29.5) | |
| ≥3 | 70 (38.0) | 19 (21.3) | 51 (53.7) | |
| Septic shock, n (%) | 49 (26.6) | 14 (15.7) | 35 (36.8) | 0.001 |
| Laboratory results | ||||
| ESR, mm/h, mean (SD) | 67.9 (32.6) | 70.8 (33.5) | 63.9 (31.5) | 0.40 |
| WBC × 109/L, mean (SD) | 15.9 (9.1) | 15.1 (9.0) | 16.8 (9.2) | 0.19 |
| CRP mg/L, mean (SD) | 313.5 (183.9) | 330.1 (186.6) | 297 (180.8) | 0.21 |
SD: standard deviation; Q1–Q3: 1st quartile–3rd quartile; SAPS II: simplified acute physiology score II; ESR: erythrocyte sedimentation rate; WBC: white blood cells; CRP: C-reactive protein.