(a)  

Group	n	Body weight (g)	FBG (mmol/L)	FSI (ug/L)	TC (mmol/L)	LDL-C (mmol/L)	ISI
db/m	Baseline 20	29.10 ± 0.33*	5.51 ± 0.53*	2.43 ± 0.23*	2.65 ± 0.41*	1.65 ± 0.22*	−2.58 ± 0.15
	Terminal 20	35.80 ± 0.54*	5.71 ± 0.63*	2.63 ± 0.31*	2.55 ± 0.53*	1.79 ± 0.27*	−2.69 ± 0.19
db/db	Baseline 20	41.20 ± 3.18	17.30 ± 3.99	8.51 ± 1.26	5.14 ± 0.80	3.88 ± 0.44	−4.95 ± 0.32
	Terminal 20	50.20 ± 4.32	25.9 ± 2.00	9.55 ± 1.20	5.86 ± 0.85	4.91 ± 0.37	−5.49 ± 0.20
Ezetimibe	Baseline 20	40.92 ± 2.84	18.37 ± 4.25	9.01 ± 1.37	5.30 ± 0.77	3.69 ± 0.74	−5.07 ± 0.34
	Terminal 20	45.40 ± 3.81*	18.82 ± 3.99*	7.58 ± 0.67*	4.21 ± 0.63*	2.78 ± 0.62*	−4.38 ± 0.24

Note: db/m: db/m mice without diabetes; db/db: untreated db/db mice with diabetes; ezetimibe: ezetimibe-treated db/db mice with diabetes; *P < 0.05 untreated db/db mice versus treated db/db control mice.