Skip to main content
. 2012 Oct 30;6:156. doi: 10.3389/fnins.2012.00156

Figure 5.

Figure 5

Comparison with previously published miR-124 targets. (A,B) The Venn diagrams show counts of putative direct targets of miR-124 that were inferred from the transfection experiments in this work and from the published HITS-CLIP sequencing (Chi et al., 2009) and microarray (Lim et al., 2005) experiments. The latter study is based on HeLa transfrection experiment. The mouse homologs of human miR-124 targets were retrieved from HomoloGene http://www.ncbi.nlm.nih.gov/homologene; (C) the Venn diagram shows counts of miR-124 targets reported in HeLa study (Lim et al., 2005) and transcripts induced by transfection alone in our experiment. In all cases the test universe was 3,465 mouse transcripts, with 3′UTRs containing one or more 7(2) or 7(1A)-type seed matching site for miR-124. The test universe was a complete list of mouse genes encoding transcripts with 3′UTRs containing one or more 7(2) or 7(1A)-type seed matching site for miR-124, and which were represented on Illumina Sentrix BeadChip Array Mouse-WG6 v2 microarray platform (3,465 genes in total). The text shows fold enrichment above what is expected by chance alone and the hypergeometric P-value for the intersection.