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. Author manuscript; available in PMC: 2013 Jun 11.
Published in final edited form as: Angew Chem Int Ed Engl. 2012 Apr 27;51(24):5876–5879. doi: 10.1002/anie.201200526

Figure 1.

Figure 1

Design and validation of a minimal hTR pseudoknot smFRET construct. a) Schematic diagram of smFRET minPK construct. Nucleotide numbering corresponds to the native full-length hTR sequence. b) FRET distribution for minPKWT (U92-Cy3/U184-Cy5). c) FRET distribution for minPKWT (U105-Cy3/U184-Cy5). Data in (b) and (c) were acquired in the presence of telomerase imaging buffer containing 1 mM Mg2+.