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. Author manuscript; available in PMC: 2012 Oct 30.
Published in final edited form as: Leukemia. 2011 Jun 10;25(10):1610–1619. doi: 10.1038/leu.2011.120

Figure 5. HLA-A2-restricted and antigen-specific cytotoxicity of the XBP1-CTLs.

Figure 5

The specific cytotoxic activities of the heteroclitic XBP1-CTLs were analyzed one week after their 4th stimulation using the calcein cytotoxicity assay. A high level of cytotoxic activity against U266 (MM, HLA-A2+/XBP1+) (♦) and McCAR (MM, HLA-A2+/XBP1+) (■), but not against the ML-2 (AML, HLA-A2+/XBP1−) (▲) and MM1S (HLA-A2−/XBP1+) (X) cell lines was demonstrated by both the (a) heteroclitic XBP1184–192 CTLs and (b) heteroclitic XBP1 SP367–375 -CTLs. The values represent the mean±SE of three separate experiments.