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SCD and hemizygous mice have decreased serum IgG2b, IgM, and IgA levels, but increased IgG2a production. A–D: Serum immunoglobulins from C57BL/6 (n = 11), hemizygous (Hemi; n = 11), and SCD (n = 9) mice are analyzed via Luminex bead assay. Bars represent mean ± SEM levels. Significant differences are determined by one-way analysis of variance with multiple pairwise comparisons between groups using the Newman-Keuls post hoc test. *P < 0.05, **P < 0.01, and ***P < 0.001.
