Figure 6.

The SCD mouse spleen is grossly enlarged and has distorted histological organization. SCD spleens are six times larger by wet weight than hemizygous and C57BL/6 spleens (A), which is evident on gross examination (B). Histologically, on standard H&E staining at an original magnification of ×4, SCD splenic tissue has a markedly distorted organization (D) compared with C57BL/6 mice (C), which have organized areas of white pulp and red pulp. Significant differences are determined by one-way analysis of variance with multiple pairwise comparisons between groups using the Newman-Keuls post hoc test. ***P < 0.001.