Table 8.
Comparison of prophylactic irradiation, loco-regional control, and salvage surgery
| Series | Treatment period | No. of Pts | median f/u (M) | 5yr-OS (%) | Prophylactic RT yes/no | Prophylactic dose (Gy) | No. of nodal rec. | No. of local rec. | No. of salvage sx for local rec. |
|---|---|---|---|---|---|---|---|---|---|
| Nakamuraa [1] | 1976–2002 | 43 | 52 | 70 | 35/8 (81%) | 30–50 | 3 (7%) | 2 (5%) | 2 (100%) |
| Nakamurab [2] | 1990–2001 | 115 | 47 | 66 | 90/25 (78%) | 36–50 | 14 (12%) | 30 (26%) | 26 (87%) |
| Yoshimura [10] | 1988–2007 | 77 | 33 | 47 | 66/11 (86%) | 20–50 | 11 (14%) | 16 (21%) | 12 (75%) |
| Current study | 1991–2010 | 45 | 53 | 81 | 45/0 (100%) | 40–50 | 0 (0%) | 8 (18%) | 8 (100%) |
aEleven of 43 patients received surgery after 30–40 Gy irradiation.
bQuestionnaire collected from 10 institutions.
Pts = patients, f/u = follow-up period, M = months, OS = overall survival rate, RT = radiation therapy, rec. = recurrence, sx = surgery.