Table 1.

Antiprotozoal activities of the 2-alkynoic fatty acids. The IC₅₀ values are in μM.

Compounds	Trypanosoma brucei rhodesiense	Trypanosoma cruzi	Leishmania donovani	L6 cell cytotoxicity
2-TDA	255.4	62.4	24.7	40.9
2-HDA	83.6	80.0	17.8	340.3
2-ODA	64.5	48.1	11.0	20.0
Standard	0.0075a	1.47b	0.49c	0.02d

The values represent the average of at least two independent assays performed in duplicates.

Reference compounds are:

^aMelarsoprol

^bBenznidazole

^cMiltefosine

^dPodophyllotoxin.