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. Author manuscript; available in PMC: 2012 Oct 30.
Published in final edited form as: J Agric Food Chem. 2010 Oct 19;59(7):2816–2824. doi: 10.1021/jf102559q

Figure 3.

Figure 3

EFAs block inflammatory pain. Area under the curve (efficacy vs. time) for key EFAs with and without the sEHI AUDA-be (butyl ester) using the Hargreaves thermal hyperalgesia test (n=4 per group) is shown. Control animals did not receive LPS, and thus are not inflamed. LPS group received a single intraplantar injection of LPS (10 μg) in one hind paw. All EFAs and sEHI were formulated in Vanicream® and administered topically at a dose of (50 mg/kg) as described (29). LPS injection dramatically reduces the threshold for pain decreasing the latency of thermal withdrawal responses, thus this group has a lower AUC. EFAs of DHA, EPA and AA were equally effective in reducing pain. The sEHI AUDA-butyl ester was also highly efficacious in eliminating inflammatory pain. Co administration of EETs with sEHI prolonged the efficacy of the EETs and produced an additive effect in reducing pain.