Table 1.
Enrichment results for primary analyses
Diagnosis | Ancestry | Parietal enrichment | Cerebellar enrichment | Lymphoblastoid cell line enrichment |
---|---|---|---|---|
Spectrum |
All |
P = 0.004 |
P = 0.003 |
P = 0.502 |
Nsnps = 1262 |
|
|
|
|
Nsubs = 1385 |
|
|
|
|
Strict |
All |
P <0.001 |
P = 0.872 |
P = 0.110 |
Nsnps = 991 |
|
|
|
|
Nsubs = 812 |
|
|
|
|
Spectrum |
Western European |
P = 0.005 |
P = 0.012 |
P = 0.503 |
Nsnps = 1209 |
|
|
|
|
Nsubs = 1230 |
|
|
|
|
Strict |
Western European |
P <0.001 |
P = 0.451 |
P = 0.496 |
Nsnps = 998 |
|
|
|
|
Nsubs = 720 |
Results for primary analyses are shown by diagnostic category and ancestry. The number of subjects (Nsubs) that went into the GWAS, and the subsequent number of SNPs (Nsnps) that were significant at a GWAS P <10-3 and went into the eQTL enrichment analysis is shown in each diagnostic and ancestry category. The empirically derived enrichment P-value for each diagnostic and ancestry category in each tissue tested is also provided. eQTL: expression quantitative trait loci; GWAS: genome-wide association study; SNP: single nucleotide polymorphism.