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. 2012 Oct 23;8:78. doi: 10.1186/1744-8069-8-78

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Copyright ©2012 Chai et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Inhibition of IL-1R in the ipsilateral Vi/Vc attenuates contralateral hyperalgesia. Contralateral orofacial hyperalgesia is attenuated by IL-1R inhibition in the ipsilateral Vi/Vc. A, B. Post-treatment: CFA (0.05 ml; 1:1 oil/saline) was injected unilaterally into the masseter muscle 24 h prior to IL-1ra microinjection into the ipsilateral Vi/Vc (0.5μl). C, D. Pre-treatment: CFA (0.05 ml; 1:1 oil/saline) was injected unilaterally into the masseter muscle 15 min after IL-1ra microinjection into the ipsilateral Vi/Vc (0.5 μl). Pre-treatment and post-treatment of IL-1ra attenuated CFA-induced contralateral hyperalgesia as compared to saline treated rats. IL-1ra did not attenuate ipsilateral hyperalgesia. *: IL-1ra (5 nmol) vs saline. *: p<;0.05; **: p<;0.01; ***: p<;0.001 (ANOVA with repeated measures and Student Neuman-Keuls post-hoc test).