Table 1. Description of the 3 asthmatic mouse models.

	Group A (Days 35–37)			Group B (Days 75–77)			Group C (Days 110–112)
	Control(n = 8)	OVA(n = 8)	P-value	Control(n = 9)	OVA(n = 10)	P-value	Control(n = 8)	OVA(n = 8)	P-value
Weight at endpoint (g)	18.4±0.3	18.9±0.4	0.234	22.33±0.4	21.1±0.6	0.150	24.3±0.8	23.4±0.5	0.450
Plethysmography
Penh ratio at baseline	2.3±0.3	2.4±0.3	0.916	2.5±0.3	2.0±0.2	0.156	2.3±0.4	2.4±0.3	0.959
Penh ratio at endpoint	3.5±0.5	10.0±3.6	0.001	3.4±0.8	7.5±1.4	0.045	2.8±0.3	3.5±0.6	0.279
BAL
Total cells (× 104/mL)	36.4±7.5	48.6±6.8	0.105	35.6±2.3	76.9±12.8	<0.001	24.0±2.4	36.0±5.8	0.172
% macrophages	93.3±2.1	86.4±2.8	0.050	91.8±0.6	60.4±9	0.013	95.8±1.3	93.7±1.6	0.382
% neutrophils	3.3±1.2	3.2±2.8	0.125	3.2±1.2	18±7	0.573	0.8±0.1	1.5±0.7	0.421
% eosinophils	0.6±0.6	4.2±0.9	0.003	0.4±0.4	10.6±3.1	0.002	0.0±0.0	0.1±0.1	0.160
% lymphocytes	2.8±1.4	6.3±1.6	0.038	4.7±0.9	11±2.1	0.081	3.4±1.2	4.6±1.7	0.878
Histological data
Peribronchial space area(µm2)	14.5±2.2	25.6±5.1	0.083	13.6±1.2	56.2±10.2	<0.001	11.3±1.3	14.4±1.43	0.083
Number of nucleated cellswithin the peribronchialspace area (cell/µm2)	106.8±11.9	171.2±28.4	0.028	138.6±19.2	505±85	<0.001	76.7±7.1	102.3±9.7	0.028
Basal membrane thickness(µm)	5.4±0.3	5.9±0.2	0.065	5.3±0.4	10.2±0.9	<0.001	5.5±0.3	8.9±0.6	<0.001
Wall area (µm2/bronchus)	17.4±2.4	18.4±1.4	0.442	16.7±1.0	25.4±1.6	<0.001	16.2±0.7	24.5±2.4	<0.001
Bronchial muscle area(× 103 µm2/bronchus)	4.3±0.9	3.6±0.5	0.798	4.1±0.8	6.6±0.9	0.035	3.6±0.4	6.9±0.6	0.002
Peribronchial fibrosis(× 103 µm2)	1.9±0.6	2.8±0.4	0.105	2.6±0.4	6.1±1.1	0.012	2.0±0.3	5.6±1.2	0.005

Data are means ± standard error of the mean. P-values were obtained using Wilcoxon-Mann-Whitney rank sum test. BAL: bronchoalveolar lavage.